Abstract
Urinary metabolites of scutellarin, the main effective constituent of breviscapine,
a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of
rats following oral administration of scutellarin and identified as scutellarein 6,7-di-O-β-D-glucuronide (M1) and scutellarein (M2), respectively, on the basis of chemical and
spectroscopic evidence. M1 was reported as a metabolite of scutellarin for the first
time.
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Prof. Feng Qiu
Department of Natural Products Chemistry
Shenyang Pharmaceutical University
No.103 Wenhua road
Shenyang
110016 Liaoning
People’s Republic of China
Phone: +86-24-2398-6463
Fax: +86-24-2399-3994
Email: fengqiu2000@tom.com
